منابع مشابه
Life at the Leading Edge
Cell migration requires sustained forward movement of the plasma membrane at the cell's front or "leading edge." To date, researchers have uncovered four distinct ways of extending the membrane at the leading edge. In lamellipodia and filopodia, actin polymerization directly pushes the plasma membrane forward, whereas in invadopodia, actin polymerization couples with the extracellular delivery ...
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متن کاملContact Angle at the Leading Edge Controls Cell Protrusion Rate
Plasma membrane tension and the pressure generated by actin polymerization are two antagonistic forces believed to define the protrusion rate at the leading edge of migrating cells [1-5]. Quantitatively, resistance to actin protrusion is a product of membrane tension and mean local curvature (Laplace's law); thus, it depends on the local geometry of the membrane interface. However, the role of ...
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The intracellular pathogen Listeria monocytogenes is a useful model for general actin-based cell motility, because it recruits host actin and associated proteins for movement. Recent data have shown that these associated proteins include the Ena/VASP family of proteins and the actin-related proteins Arp2 and Arp3.
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ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.06.010